The Challenge: Vision Loss from Diabetic Retinal Disease (DRD)
Many of you know Mary Tyler Moore by her work as an actress and diabetes research advocate. Her professional persona was one of joy and optimism, yet very few people knew of the burden she carried due to her struggles with diabetes and its complications. To the outside world, she was a beautiful, happy, independent woman. Privately, diabetes and her near-blindness from diabetic retinal disease (DRD) stole her joy and autonomy.
Sadly, Mary’s story is not unique. Everyone with diabetes knows the fear of possible vision loss. Tens of millions of individuals worldwide suffer from blindness and vision-threatening retinal disease as a complication of type 1 or type 2 diabetes. DRD is, in fact, the leading cause of blindness in working-age adults worldwide, with more than 50 million people suffering from vision-threatening DRD globally.
Our Response: A Multi-Phase Initiative to Preserve and Restore Vision in People with Diabetes
Recent decades have given rise to great advances in retinal imaging technology, gene therapy, regeneration science, and the understanding of the neurologic component of DRD and the cellular and molecular basis for this disease. Thanks to these advances, there is hope that vision restoring treatments and new ways to prevent visual loss and blindness for people with diabetes are now within our reach. However, these breakthroughs require committed collaborations, access to specialized resources, and real-time data sharing between innovators across the spectrum of expertise. The Mary Tyler Moore Vision Initiative (MTM Vision) is establishing the enabling resources and collaborations, bringing cross-sector expertise together, and supporting the scientific programs needed to accelerate research and development of new therapies. Our ultimate goal is to create a world without vision loss from Diabetic Retinal Disease.
Phase 1 of MTM Vision provides critical-path resources to address three key barriers to accelerated progress::
Successes in our Phase 1 will help:
• Establish new indications for treatments in DRD, including in earlier stage disease
• Enable identification of new therapeutic targets at molecular and cellular level
• Inform new regulatory pathways for drug approvals
To realize the full value of our Phase 1 projects, we are establishing a cross-sector, pre-competitive consortium to provide members access to our unique biospecimen and data assets to support their relevant research efforts… thereby accelerating progress toward development and approval of new ways to preserve and restore vision in people with diabetes.
(See our “Milestones” document included later in this Program Book for summary of Phase 1 progress)
Phase 2 of MTM Vision will advance DRD diagnostic capabilities and support novel Therapeutics Targets Identification:
1. Retinal Imaging Core. Large, integrated data sets obtained across diverse clinical settings and conditions, from a range of ethnicities and environments, are needed for development of advanced, automated, AI-based diagnostic systems targeting improving clinical outcomes and reducing health care inequities. In its Phase 2, the Mary Tyler Moore Vision Initiative will develop a retinal image bank to support aggregation and analysis of millions of digital images aligned with functional measures and de-identified longitudinal patient data. The image bank data-sharing platform will constitute a core research resource offered to the community of qualified scientists and Vision Initiative collaborators and will include systematic data capture, data integration and harmonization, and capacity for hypothesis testing with cloud-based research and training.
Phase 3 of the Mary Tyler Moore Vision Initiative will organize and support outcomes-driven, science with a mission programs designed to develop new methods to preserve and restore vision in people with diabetes, including programs that focus on methods to:
1. Tomilo M, Ascani H, Mirel B, Magnone MC, Quinn CM, Karihaloo A, Duffin K, Patel UD, Kretzler M. Renal Pre-Competitive Consortium (RPC(2)): discovering therapeutic targets together. Drug discovery today. 2018;23(10):1695-9. Epub 2018/05/21. doi: 10.1016/j.drudis.2018.05.021. PubMed PMID: 29778696.
2. Levine SR, Myers MG, Jr., Barunas R, Chang D, Dutta S, Maddess T, Liebmann JM, Sherman S, Eydelman M, Sun JK, Chambers W, Wickstrom K, Luhmann UFO, Pellinat M, Glassman A, Aiello LP, Markel DS, Gardner TW. Report from the 2022 Mary Tyler Moore Vision Initiative Diabetic Retinal Disease Clinical Endpoints Workshop. TVST. in press.
For more information, please e-mail S. Robert Levine, MD at firstname.lastname@example.org
The Mary Tyler Moore Vision Initiative’s audacious goals are to preserve and restore vision in people with diabetes. It is a joint effort of The Mary Tyler Moore and S. Robert Levine, MD Charitable Foundation, The University of Michigan’s Elisabeth Weiser Caswell Diabetes Institute and Kellogg Eye Center, JDRF, and the Entertainment Industry Foundation (EIF)
Mary Tyler Moore Vision Initiative is a fund of the Entertainment Industry Foundation (EIF), a Charity Navigator Four-Star Charity that meets all 20 Better Business Bureau charity standards and carries the Candid Platinum Seal of Transparency.